This issue of Veterinary Clinics: Food Animal Practice, guest edited by Drs. Amelia Woolums and Douglas Step, focuses on Bovine Respiratory Disease. This is one of three issues each year selected by the series consulting editor, Dr. Robert A. Smith. Articles in this issue include, but are not limited to: BRD from the 20th century to now: has anything changed?; Mannheimia haemolytica and Pasteurella multocida: how are they changing in response to our efforts to control them?; Mycoplasma bovis: what characteristics of this agent explain the disease that it causes?; Histophilus somni: antigenic changes relevant to BRD; The microbiome and BRD; Viruses in Bovine Respiratory Disease in North America: Knowledge Advances Using Genomic Testing; The Immunology of Bovine Respiratory Disease: Recent Advancements; Host tolerance to infection with the bacteria that cause bovine respiratory disease; How does nutrition influence BRD?; How does housing influence BRD?; Diagnostic tests for BRD; Details to attend to when managing high risk cattle; BRD Vaccination: MLV vs Killed? IN vs Parenteral? What is the evidence?; Timing of BRD Vaccination; Causes, significance, and impact of BRD treatment failure; The effect of market forces on BRD; and The future of BRD management in the era of precision agriculture, rapid DNA sequencing, and bioinformatics.