This second edition is a result from a worldwide surge of interest in antiphospholipid syndrome. This disease, also known as Hughes Syndrome, affects all organs of the body including the placenta, and therefore touches all areas of medicine. Many publications have shown that APS causes miscarriage, strokes, heart attacks and teenage epilepsy. This new edition will see many of the illustrations updated as well as an increase in the number of figures within the chapters, to help the reader understand and treat this disease. It aims to help patients with Hughes Syndrome and their families, as well as trainee doctors , GPs, nurses and midwives.