As a cultural centre for Islamic interests across the world and as a focus point for increasing levels of economic and security interdependence, the Middle East remains a stage on which international politics will be played for the foreseeable future. This comprehensive study looks at the important international and regional actors and their interaction with, and reaction to, US foreign policy toward the region. The volume elucidates the trends in great power interest and interaction in the Middle East and studies the impact of the United States as the region's foremost military power. It highlights the changing nature of actors' relationships with the US and each other as their interests and policies evolve in response to changes in the region. Scholars, graduate and undergraduate students and the interested public will find this volume a useful guide and an ideal companion work for courses on the Middle East, US foreign policy and international security issues.