Cerebral Palsy (CP) represents one of the most frequent neurological disorder in the infancy and in the childhood. It includes brain injuries or developmental defects. According to the World Health Organization, it is a main problem of public health. It may include communication, intellectual, and motor disabilities with negative consequences on children inclusion in daily life and caregivers burden. Rehabilitative interventions are primarily focused on promoting self-determination and independence of individuals with CP. Postural control, gait, and motor skills are usually embedded. Additionally, one may envisage request and choice programs aimed at enhancing the child's awareness of his/her own behavior. The volume summarizes some illustrative evidence-based contributions to emphasize the effectiveness and the suitability of the adopted programs. Beside stability of upper limbs and motor performance of children with CP (chapter one), the therapeutic effects of a horse riding simulator which was compared to a traditional physiotherapy on the sitting position of children with spastic CP (chapter two), the evaluation of stability in children with different form of CP was assessed through a rehabilitative platform was implemented (chapter three). The aforementioned experimental examinations presented between-groups investigations. Furthermore, four case-report studies were included. Assistive technology-based setups were used to promote an active role, constructive engagement, and positive participation of the enrolled children with CP and intellectual disabilities. The beneficial outcomes on their quality of life were considered. Chapter four describes a microswitch-based program to enhance ambulation responses of a child with CP. Chapter five provides a detailed illustration of such program to support locomotion fluency. Chapter six illustrates a cluster-technology aimed at pursuing the dual goal of fostering an adaptive response and reducing a challenging behavior. Chapter seven refers to a computerized system focused on enabling a child with CP and intellectual delays with academic performance and communication opportunities. Whenever available, the effects on indices of happiness and/or positive participation were analyzed. Social validation procedures involving external raters were conducted. Practical features of the retained treatments were privileged. Clinical, educational, psychological, and rehabilitative implications of the findings were systematically and critically discussed. Caregivers, educators, families of children with CP, practitioners, psychologists, speech and occupational therapists, medicine or psychology students, and teachers may find some useful insights for both research and practice in daily life settings.