This book contains the proceedings of two long-running events held along with the CAiSE conference relating to the areas of enterprise, business-process and information systems modeling: * the 22nd International Conference on Business Process Modeling, Development and Support, BPMDS 2021, and * the 26th International Conference on Exploring Modeling Methods for Systems Analysis and Development, EMMSAD 2021. The conferences were planned to take place in Melbourne, Australia, during June 28â¤"29, 2021, but changed to an online format due to the COVID-19 pandemic. For BPMDS 10 full papers and 1 short paper were carefully reviewed and selected for publication from a total of 26 submissions; for EMMSAD 13 full papers and 1 short paper were accepted from 34 submissions. The papers were organized in topical sections as follows: BPMDS: Improving event data quality in coherence with business requirements; enhancing the value of data in processesimprovement; event stream and predictive monitoring; modeling languages and reference models; EMMSAD: Enterprise modeling; handling models and modeling methods; threat and evidence modeling; and model-driven engineering and applications.